LGI2 Truncation Causes a Remitting Focal Epilepsy in Dogs

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LGI2 Truncation Causes a Remitting Focal Epilepsy in Dogs

One quadrillion synapses are laid in the first two years of postnatal construction of the human brain, which are then pruned until age 10 to 500 trillion synapses composing the final network. Genetic epilepsies are the most common neurological diseases with onset during pruning, affecting 0.5% of 2-10-year-old children, and these epilepsies are often characterized by spontaneous remission. We p...

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BACKGROUND Previous work has identified elevated prevalence rates for psychiatric disorders in individuals with medically refractory focal epilepsy, particularly temporal lobe epilepsy. Many studies were undertaken before the advent of video electroencephalogram monitoring (VEM) and magnetic resonance imaging (MRI). AIMS To investigate which characteristics of the focal epilepsy syndromes are...

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Prevalence of nonlesional focal epilepsy in an adult epilepsy clinic.

PURPOSE To evaluate the prevalence of nonlesional focal epilepsy in an adult epilepsy clinic and its refractoriness to antiepileptic drug therapy. BACKGROUND Focal epilepsy is frequently, but not always, associated with structural epileptogenic lesions identifiable on magnetic resonance imaging (MRI). METHODS We analyzed the data from all patients evaluated at an adult epilepsy clinic from ...

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ژورنال

عنوان ژورنال: PLoS Genetics

سال: 2011

ISSN: 1553-7404

DOI: 10.1371/journal.pgen.1002194